May 26, 2026
Created by Ryan Hale

C4 Pre Workout Ingredients: 9 Facts From the Current Label

SUPPLEMENTS · PRE WORKOUT LABEL REVIEW

C4 PRE WORKOUT INGREDIENTS: 9 FACTS FROM THE CURRENT LABEL

C4 pre workout is one scoop of 8.9 g with 200 mg of caffeine, 2 g of beta alanine and 1 g of creatine nitrate. The current 5th Gen label also adds 100 mg of lentil peptides called PeptiPump.

This review reads the C4 pre workout ingredients line by line. For each one, we compare the label dose with the dose used in research. Label figures come from Cellucor; study figures come from PubMed, all listed at the end. For a stimulant free option, see our non stim pre workout guide.

R
Ryan Hale
Research Notes Editor · Updated October 2026

C4 pre workout in three numbers

Three numbers on the C4 Original pre workout label tell you most of what the scoop will do.

200mg caffeine

Per scoop, printed on the panel

About as much as two small cups of coffee, as a rule of thumb (Cellucor label).

2 gbeta alanine

CarnoSyn, the cause of the tingle

Studies that raised muscle carnosine used 3.2 g a day or more (PMID 16554972).

1 gcreatine nitrate

Not the same as 1 g of creatine

Roughly two thirds of it is creatine by weight, by our arithmetic (Cellucor label).

Label figures come from the C4 Original 5th Gen Supplement Facts panel on cellucor.com, checked on 27 October 2026. The tub got a new look in 2026, but the 5th Gen formula and 30 servings per 267 g tub stay the same. We do not sell this product and take no payment for reviews.

What this C4 pre workout review covers

Covered

Every C4 pre workout ingredient on the current panel, with its dose.

Caffeine: how much is in C4 pre workout and how it compares with safety limits.

Doses vs studies for beta alanine, citrulline, arginine and creatine nitrate.

Not covered

Flavor rankings and prices. Both change; this is a label and evidence review.

C4 pre workout ingredients: the full label

Here are the C4 pre workout ingredients per scoop, in the order Cellucor prints them (Cellucor label).

C4 Original pre workout ingredients per scoop (8.9 g), 5th Gen panel.
IngredientPer scoopGroup on the label
Caffeine anhydrous200 mgEnergy and focus
Huperzia serrata extract (1% huperzine A)5 mgEnergy and focus
CarnoSyn beta alanine2 gEndurance
L-citrulline1.2 gVelox blend (pump)
L-arginine1.2 gVelox blend (pump)
PeptiPump lentil peptides100 mgVelox blend (pump)
Creatine nitrate (NO3-T)1 gPerformance
Choline225 mgNutrient
Vitamin B6, folate, B123.4 mg, 100 mcg DFE, 6 mcgVitamins
Calories, carbs, sugar10 kcal, 1 g, 0 gNutrition

Other ingredients are acids, flavors, flow agents, sucralose, acesulfame potassium and spirulina extract for color (Cellucor label).

Good news: every dose is printed. The Velox blend shows each part in grams, so nothing is hidden in a proprietary total.

The label warns that the product is for adults 18 and over, and not for pregnant or nursing women (Cellucor label).

YouWhat this means for you. With C4 pre workout you can see every dose. That lets you judge each ingredient against the research, which is what the rest of this page does.

How much caffeine is in C4 pre workout?

One scoop of C4 Original pre workout has 200 mg of caffeine anhydrous (Cellucor label). C4 Sport also has 200 mg, and C4 Ultimate has 300 mg (Cellucor product pages).

Caffeine is the ingredient with the best evidence. The caffeine position stand found benefits at 3 to 6 mg per kg of body weight (PMID 33388079).

The same paper says the minimum effective dose may be as low as 2 mg per kg. Very high doses, like 9 mg per kg, caused more side effects (PMID 33388079).

C4 pre workout caffeine per scoop, as mg per kg of body weight (our arithmetic).
Body weightmg per kg from 1 scoopInside 3 to 6 mg/kg?
60 kg3.3Yes
70 kg2.9Just below
80 kg2.5Below, above 2
100 kg2.0At the possible minimum
400FDA has cited 400 mg of caffeine a day as an amount not generally linked to negative effects for most adults (FDA).

One scoop is half of that daily amount. Coffee, energy drinks and a second scoop all count toward the same total (FDA).

The position stand notes that caffeine can affect sleep and anxiety, and that people respond differently (PMID 33388079).

C4 pre workout ingredients review: young classic physique athlete in a gym mixing one scoop of pre workout powder into a plain shaker bottle
Rule of thumb: count every source of caffeine in your day, not just the scoop.
YouWhat this means for you. For most adults, one scoop of C4 pre workout is a moderate, research range dose of caffeine. Avoid two scoops plus coffee, and avoid it late in the day if sleep matters.

Beta alanine in C4 pre workout: the tingle and the dose

Beta alanine raises carnosine in muscle, which buffers acid during hard efforts. The tingle on your skin is the known side effect.

The beta alanine position stand says 4 to 6 g a day for at least 2 to 4 weeks improved performance. Effects were clearest in efforts lasting 1 to 4 minutes (PMID 26175657).

It also says tingling can be reduced with divided doses of about 1.6 g, or a sustained release form (PMID 26175657).

In an early study, 3.2 g a day for 4 weeks raised muscle carnosine by about 42 percent (PMID 16554972).

A meta analysis found the clearest benefit in exercise lasting 60 to 240 seconds, and no clear benefit under 60 seconds (PMID 22270875).

YouWhat this means for you. One scoop of C4 pre workout gives half of the 4 g daily research dose. Beta alanine works by daily use over weeks, not by one scoop before a set.

Citrulline, arginine, PeptiPump and creatine nitrate

L-citrulline and L-arginine

C4 Original pre workout gives 1.2 g of L-citrulline and 1.2 g of L-arginine (Cellucor label).

The citrulline research used much larger doses of a different form. A meta analysis of 6 to 8 g of citrulline malate found about 6 percent more reps (PMID 34010809).

In one trial, 8 g of citrulline malate increased bench press reps and cut soreness (PMID 20386132). That form and dose are not what C4 contains.

A review of nitric oxide supplements found mixed results for arginine and citrulline in trained people (PMID 22260513).

PeptiPump

PeptiPump is listed as 100 mg of lentil peptides (Cellucor label). We found no human trial on PubMed for this ingredient. Treat any pump claim as unproven.

Creatine nitrate

Creatine nitrate is creatine bound to nitrate. Roughly two thirds of its weight is creatine, so 1 g gives about 0.67 g of creatine, by our arithmetic.

The creatine position stand describes a habitual intake of about 3 g a day (PMID 28615996). Higher loading doses are also used.

In a 28 day trial, 3 g of creatine nitrate a day was well tolerated and performed like 3 g of creatine monohydrate (PMID 27034623).

Huperzine A

Huperzia serrata extract at 5 mg with 1 percent huperzine A works out to about 50 mcg of huperzine A, by our arithmetic.

A 2023 review of memory supplements found mixed results for huperzine A (PMID 37603263). We found no strong trial for training focus.

YouWhat this means for you. In C4 pre workout, the pump and creatine parts are present but small. If you want the creatine benefit, take creatine every day on its own.

C4 pre workout doses vs research doses

This chart shows how much of each research dose one scoop of C4 pre workout supplies.

C4 label dose vs the dose used in studiesPercent of the research dose that one scoop supplies. 100 percent = matches the studies.Caffeine 200 mg83%Beta alanine 2 g50%Creatine part, ~0.67 g22%Research doses: 3 mg/kg for an 80 kg adult (240 mg), 4 g a day, 3 g a day. Our arithmetic.
C4 label dose vsthe dose used in studiesPercent of the research dosein one scoop. 100% matches studies.Caffeine 200 mg83%Beta alanine 2 g50%Creatine part, ~0.67 g22%Research: 240 mg (80 kg), 4 g/day,3 g/day. Our arithmetic.
C4 pre workout label dose vs the dose used in research.
IngredientC4 per scoopResearch doseVerdict
Caffeine200 mg3 to 6 mg/kg (PMID 33388079)In range for many adults
Beta alanine2 g4 to 6 g a day for weeks (PMID 26175657)Half dose
Creatine (from nitrate)About 0.67 gAbout 3 g a day (PMID 28615996)Low
Citrulline1.2 g L-citrulline6 to 8 g citrulline malate (PMID 34010809)Low, different form
PeptiPump100 mgNo human trial foundUnproven
C4 pre workout doses explained: young mens physique athlete training on a cable machine in a gym with a plain shaker bottle on the floor
Rule of thumb: the scoop is mainly a caffeine product; the other doses are below research levels.
YouWhat this means for you. C4 pre workout works mainly through its caffeine. The other ingredients are real but underdosed compared with the studies.

9 facts from the current C4 pre workout label

1. One scoop is 8.9 g, 30 scoops per tub. (Cellucor label)

2. 200 mg caffeine per scoop, printed on the panel (Cellucor label).

3. 2 g CarnoSyn beta alanine, half the 4 g daily research dose (PMID 26175657).

4. 1 g creatine nitrate, about 0.67 g of creatine by our arithmetic.

5. 1.2 g L-citrulline and 1.2 g L-arginine in the Velox blend (Cellucor label).

6. 100 mg PeptiPump lentil peptides, new on the 5th Gen panel (Cellucor label).

7. 5 mg Huperzia serrata extract, about 50 mcg huperzine A by our arithmetic.

8. 10 calories and 0 g sugar, sweetened with sucralose and acesulfame potassium (Cellucor label).

9. Adults 18 and over only, not for pregnant or nursing women (Cellucor label).

YouWhat this means for you. C4 pre workout is honest about its doses. Read it as a 200 mg caffeine drink with extras, and it does what it says.

C4 pre workout: frequently asked questions

How much caffeine is in C4 pre workout?

C4 Original has 200 mg of caffeine per scoop. C4 Sport also has 200 mg, and C4 Ultimate has 300 mg (Cellucor product pages).

What are the main C4 pre workout ingredients?

Per scoop: 200 mg caffeine, 2 g beta alanine and 1 g creatine nitrate. The pump blend has 1.2 g L-citrulline, 1.2 g L-arginine and 100 mg PeptiPump, plus 5 mg Huperzia serrata extract (Cellucor label).

Is C4 pre workout bad for you?

For most healthy adults, one scoop gives 200 mg caffeine, half of the 400 mg a day FDA has cited for most adults (FDA). The label says adults 18 and over, not for pregnant or nursing women.

Why does C4 make my skin tingle?

The tingle comes from beta alanine. The position stand says divided doses of about 1.6 g or sustained release forms can reduce it (PMID 26175657).

Does C4 pre workout have creatine?

Yes, 1 g of creatine nitrate per scoop. That is about 0.67 g of creatine, below the habitual 3 g a day in the creatine position stand (PMID 28615996).

Is 200 mg of caffeine enough for performance?

Benefits were shown at 3 to 6 mg per kg, possibly from 2 mg per kg (PMID 33388079). 200 mg is 2.5 mg per kg for an 80 kg adult.

What is PeptiPump in C4?

PeptiPump is listed as 100 mg of lentil peptides in the Velox blend (Cellucor label). We found no human trial for it on PubMed.

Does citrulline in C4 increase reps?

Studies that found more reps used 6 to 8 g of citrulline malate (PMID 34010809). C4 has 1.2 g of L-citrulline.

Sources and further reading

Every figure on this page comes from one of the 13 sources below. That is two Cellucor pages, one FDA page and 10 papers checked against PubMed on 27 October 2026. Per kg doses, percent of research dose and the creatine and huperzine A amounts are our own arithmetic. Reference links are dofollow to support open science.

1
C4 Original Pre Workout, 5th Gen: Supplement Facts

Verified

Cellucor, cellucor.com, checked 27 October 2026 (Icy Blue Razz panel). Serving 1 scoop (8.9 g), 30 servings: 10 kcal, 1 g carbohydrate, 0 g sugar; vitamin B6 3.4 mg, folate 100 mcg DFE, vitamin B12 6 mcg, choline 225 mg; CarnoSyn beta-alanine 2 g; L-citrulline 1.2 g, L-arginine 1.2 g, PeptiPump lentil peptides 100 mg; creatine nitrate (NO3-T) 1 g; caffeine anhydrous 200 mg; Huperzia serrata extract 5 mg (1% huperzine A). Warnings: adults 18 and over; not for pregnant or nursing women.

View on cellucor.com →

2
C4 Sport and C4 Ultimate product pages

Verified

Cellucor, cellucor.com, checked 27 October 2026. C4 Sport: 200 mg caffeine per serving. C4 Ultimate: 300 mg caffeine per serving, with TeaCrine and Dynamine.

View on cellucor.com →

3
Spilling the Beans: How Much Caffeine Is Too Much?

Verified

US Food and Drug Administration, consumer update, checked 27 October 2026. FDA has cited 400 mg a day as an amount not generally associated with negative effects for most adults; rapid intake of about 1,200 mg can cause toxic effects.

View on fda.gov →

4
International society of sports nutrition position stand: caffeine and exercise performance

Verified

Guest NS, et al. J Int Soc Sports Nutr. 2021;18(1):1. PMID 33388079.

View on PubMed →

5
International society of sports nutrition position stand: Beta-Alanine

Verified

Trexler ET, et al. J Int Soc Sports Nutr. 2015;12:30. PMID 26175657.

View on PubMed →

6
The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis

Verified

Harris RC, et al. Amino Acids. 2006;30(3):279-89. PMID 16554972.

View on PubMed →

7
Effects of β-alanine supplementation on exercise performance: a meta-analysis

Verified

Hobson RM, et al. Amino Acids. 2012;43(1):25-37. PMID 22270875.

View on PubMed →

8
Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis

Verified

Vårvik FT, et al. Int J Sport Nutr Exerc Metab. 2021;31(4):350-358. PMID 34010809.

View on PubMed →

9
Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness

Verified

Pérez-Guisado J, et al. J Strength Cond Res. 2010;24(5):1215-22. PMID 20386132.

View on PubMed →

10
The effect of nitric-oxide-related supplements on human performance

Verified

Bescós R, et al. Sports Med. 2012;42(2):99-117. PMID 22260513.

View on PubMed →

11
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine

Verified

Kreider RB, et al. J Int Soc Sports Nutr. 2017;14:18. PMID 28615996.

View on PubMed →

12
Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance

Verified

Galvan E, et al. J Int Soc Sports Nutr. 2016;13:12. PMID 27034623.

View on PubMed →

13
Over the Counter Supplements for Memory: A Review of Available Evidence

Verified

Hersant H, et al. CNS Drugs. 2023;37(9):797-817. PMID 37603263.

View on PubMed →

More pre workout and supplement reviews

Four guides that sit next to C4 pre workout.

DISCLAIMER

Final Educational Note

This review is educational and is not medical advice. Label figures come from Cellucor pages on the date shown and may change; always read the tub you buy. People with heart conditions, high blood pressure, anxiety or caffeine sensitivity should talk to a doctor before using any stimulant pre workout.

MuscleScience does not sell supplements and is not paid for reviews. More guides sit on the supplements hub. Read more on the about page and in the full disclaimer.

R
Ryan Hale
Research Notes Editor. Breaks down studies, mechanisms, supplements and peptides into clear performance focused education, and checks every citation against PubMed before publication.

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